Notable Alumni of Lismore High School include:
- Peter Arnison AC, CVO - (LC 1958) Major General, Land Commander Australia 1994-1996, Governor of Queensland 1997-2003.
- Ken Buttrum - former head of the Department of Juvenile Justice of New South Wales.
- Vivian Chow Yung (1906-1941) Journalist. Founder of the "United China Magazine" in Shanghai and Foreign Affairs Editor of the "Sin Wian Pao" newspaper in Shanghai in the 1930s.
- Bruce Duncan (1928-2005) First ex-student to become Member for Lismore (1965-1988) in the New South Wales Legislative Assembly.
- Bob Ellis - (LC 1958) Writer, journalist and political commentator.
- David Ellyard - Science broadcaster and weatherman.
- Dr. Paul Hockings, author, editor, filmmaker, and Professor of Anthropology at the University of Illinois.
- Roy Masters AM - Football coach.
- Pat Morton - (1910-1999) Leader of the NSW Opposition (1955-1959) and Askin Cabinet Minister.
- John Niland AC - Vice Chancellor of the University of New South Wales 1992-2002.
- Richard Nott AM, President Australia-Britain Society, Australian Rep Friends of St. George's, CEO CGULMI 2001-2012, MD Australia MGICA 2012-16 At LHS 1954-56
- Frank Oakes - (1906-1984) (LC 1924) First ex-student to become Mayor of Lismore. Oakes Oval in Lismore is named after him.
- Bill Rixon - (1941-2003) Member of NSW Parliament for Lismore (1988–1999).
- George Sharpe (LC 1942) Justice of the Supreme Court of New South Wales 1989-1993.
- Isaac Smith - Deputy Mayor of Lismore City Council and Councillor since September 2008.
- Richard Stratford (LC 1960) Headmaster Sydney Boys' High School 1992-1999.
- Douglas G. Stuart - Regents' Professor Emeritus of Physiology, The University of Arizona.
- Harry Wharton OBE FAA - (1923-1983) Notable Zoologist and Entomologist, particularly for the CSIRO.